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Innate immune processes are sufficient for driving silicosis in mice
Author(s) -
Beamer Celine A.,
Migliaccio Christopher T.,
Jessop Forrest,
Trapkus Melanie,
Yuan Dorothy,
Holian Andrij
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0210108
Subject(s) - silicosis , inflammation , immunology , inflammasome , biology , immune system , fibrosis , innate immune system , acquired immune system , lung , medicine , pathology
Although silica‐induced fibrosis and inflammation occurs independently of T, B, NK T, and NK cells, lymphocytes regulate inflammation via modulation of the Nlrp3 inflammasome.

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