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Mechanisms and consequences of efferocytosis in advanced atherosclerosis
Author(s) -
Thorp Edward,
Tabas Ira
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0209115
Subject(s) - efferocytosis , mertk , biology , macrophage , apoptosis , inflammation , phagocytosis , immunology , necrosis , disease , lesion , pathology , microbiology and biotechnology , medicine , signal transduction , in vitro , biochemistry , receptor tyrosine kinase , genetics
Review on how dangerous atherosclerotic plaques form and the critical role for defective phagocytic clearance (or “efferocytosis”) of apoptotic macrophages in these lesions.