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IL‐21 preferentially enhances IL‐15‐mediated homeostatic proliferation of human CD28 + CD8 memory T cells throughout the adult age span
Author(s) -
Nguyen Huy,
Weng Nanping
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0209086
Subject(s) - cd28 , biology , cd8 , cytotoxic t cell , interleukin 21 , t cell , interleukin 15 , microbiology and biotechnology , immune system , il 2 receptor , immunology , cytokine , interleukin , in vitro , biochemistry
IL‐21 enhances IL‐15‐mediated proliferation of CD8 memory T cells, particularly CD28 + memory T cells, and also serves as an antagonist to the IL‐15‐induced increase of CD28 − CD8 T cells.
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