Premium
Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap‐associated cathelicidin
Author(s) -
Jann Naja J.,
Schmaler Mathias,
Kristian Sascha A.,
Radek Katherine A.,
Gallo Richard L.,
Nizet Victor,
Peschel Andreas,
Landmann Regine
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0209053
Subject(s) - cathelicidin , staphylococcus aureus , biology , microbiology and biotechnology , neutrophil extracellular traps , nadph oxidase , phagocytosis , antimicrobial peptides , innate immune system , intracellular , extracellular , antimicrobial , immunology , immune system , bacteria , inflammation , reactive oxygen species , genetics
Study took advantage of the hyper‐susceptible phenotype of S. aureus Δ dltA against cationic AMPs to investigate the impact of the murine cathelicidin CRAMP to identify its key site of action in neutrophils.