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Rapid transit in the immune cells: the role of mRNA turnover regulation
Author(s) -
Khabar Khalid S. A.
Publication year - 2007
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0207109
Subject(s) - biology , immune system , acquired immune system , microbiology and biotechnology , messenger rna , gene expression , innate immune system , regulation of gene expression , immunity , gene , immunology , genetics
There have been recent, significant advances about the role of mRNA turnover in controlling gene expression in immune cells. Post‐transcriptional regulation of gene expression contributes to the characteristics of many of the processes underlying the immune response by ensuring early, rapid, and transient action. The emphasis of this review is on current work that deals with the regulation of mRNA decay during innate immunity against microbes and T cell activation as a model of the adaptive response.