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Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice
Author(s) -
Kyrmizi Irene,
Ioannou Marianna,
Hatziapostolou Maria,
Tsichlis Philip N.,
Boumpas Dimitrios T.,
Tassiulas Ioannis
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0113039
Subject(s) - biology , phagocytosis , immunology , signal transduction , cytokine , antibody , innate immune system , microbiology and biotechnology , acquired immune system , platelet activation , immune system , platelet
Tpl2 kinase regulates FcγR‐induced MEK/ERK1/2 activation and effector functions in myeloid cells; a potential therapeutic target for immune‐complex mediated diseases.