CD8 +  dendritic cell‐mediated tolerance of autoreactive CD4 +  T cells is deficient in NOD mice and can be corrected by blocking CD40L | Zendy

Price Jeffrey D. | Zendy; Beauchamp Nicole M. | Zendy; Rahir Gwendoline | Zendy; Zhao Yongge | Zendy; Rieger Cosima C. | Zendy; LauKilby Annie W. | Zendy; Tarbell Kristin V. | Zendy

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CD8 + dendritic cell‐mediated tolerance of autoreactive CD4 + T cells is deficient in NOD mice and can be corrected by blocking CD40L

Author(s) -

Price Jeffrey D.,

Beauchamp Nicole M.,

Rahir Gwendoline,

Zhao Yongge,

Rieger Cosima C.,

LauKilby Annie W.,

Tarbell Kristin V.

Publication year - 2014

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1189/jlb.0113013

Subject(s) - biology , cytotoxic t cell , foxp3 , cd40 , cd8 , t cell , antigen presenting cell , peripheral tolerance , antigen , microbiology and biotechnology , immunology , interleukin 21 , immune tolerance , priming (agriculture) , il 2 receptor , nod mice , autoimmunity , immune system , in vitro , biochemistry , botany , germination

NOD CD8 + DCs express increased CD40; targeting of autoantigen to these cells induces Th1 responses, not tolerance, unless CD40/CD40L interactions are blocked.

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