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CD8 + dendritic cell‐mediated tolerance of autoreactive CD4 + T cells is deficient in NOD mice and can be corrected by blocking CD40L
Author(s) -
Price Jeffrey D.,
Beauchamp Nicole M.,
Rahir Gwendoline,
Zhao Yongge,
Rieger Cosima C.,
LauKilby Annie W.,
Tarbell Kristin V.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0113013
Subject(s) - biology , cytotoxic t cell , foxp3 , cd40 , cd8 , t cell , antigen presenting cell , peripheral tolerance , antigen , microbiology and biotechnology , immunology , interleukin 21 , immune tolerance , priming (agriculture) , il 2 receptor , nod mice , autoimmunity , immune system , in vitro , biochemistry , botany , germination
NOD CD8 + DCs express increased CD40; targeting of autoantigen to these cells induces Th1 responses, not tolerance, unless CD40/CD40L interactions are blocked.