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Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll‐like receptor 4/MD‐2 complex signaling in a different manner
Author(s) -
Honda Hiroe,
Nagai Yoshinori,
Matsunaga Takayuki,
Saitoh Shinichiro,
AkashiTakamura Sachiko,
Hayashi Hiroaki,
Fujii Isao,
Miyake Kensuke,
Muraguchi Atsushi,
Takatsu Kiyoshi
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0112038
Subject(s) - tlr4 , glycyrrhiza uralensis , glycyrrhizin , isoliquiritigenin , biology , toll like receptor , pharmacology , receptor , biochemistry , innate immune system , medicine , alternative medicine , pathology
GL and ILG modulate TLR4/MD‐2 complex at the receptor level, suppressing LPS‐induced activation of signaling cascades and cytokine production, with their effects exerted at different steps of TLR4/MD‐2 signaling.