Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll‐like receptor 4/MD‐2 complex signaling in a different manner | Zendy

Honda Hiroe | Zendy; Nagai Yoshinori | Zendy; Matsunaga Takayuki | Zendy; Saitoh Shinichiro | Zendy; AkashiTakamura Sachiko | Zendy; Hayashi Hiroaki | Zendy; Fujii Isao | Zendy; Miyake Kensuke | Zendy; Muraguchi Atsushi | Zendy; Takatsu Kiyoshi | Zendy

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Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll‐like receptor 4/MD‐2 complex signaling in a different manner

Author(s) -

Honda Hiroe,

Nagai Yoshinori,

Matsunaga Takayuki,

Saitoh Shinichiro,

AkashiTakamura Sachiko,

Hayashi Hiroaki,

Fujii Isao,

Miyake Kensuke,

Muraguchi Atsushi,

Takatsu Kiyoshi

Publication year - 2012

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1189/jlb.0112038

Subject(s) - isoliquiritigenin , glycyrrhizin , biology , toll like receptor , receptor , signal transduction , pharmacology , immunology , microbiology and biotechnology , innate immune system , biochemistry

GL and ILG modulate TLR4/MD‐2 complex at the receptor level, suppressing LPS‐induced activation of signaling cascades and cytokine production, with their effects exerted at different steps of TLR4/MD‐2 signaling.

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