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Staphylococcus aureus Panton‐Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome
Author(s) -
Holzinger Dirk,
Gieldon Laura,
Mysore Vijayashree,
Nippe Nadine,
Taxman Debra J.,
Duncan Joseph A.,
Broglie Peter M.,
Marketon Kristina,
Austermann Judith,
Vogl Thomas,
Foell Dirk,
Niemann Silke,
Peters Georg,
Roth Johannes,
Löffler Bettina
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0112014
Subject(s) - inflammasome , proinflammatory cytokine , panton–valentine leukocidin , biology , cytotoxic t cell , microbiology and biotechnology , inflammation , leukocidin , immunology , staphylococcus aureus , tumor necrosis factor alpha , cytotoxicity , monocyte , methicillin resistant staphylococcus aureus , bacteria , biochemistry , in vitro , genetics
Activation of the NLRP3‐inflammasome contributes to Staphylococcus aureus PVL‐associated diseases, such as necrotizing pneumonia.