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Differential expression of CD14‐dependent and independent pathways for chemokine induction regulates neutrophil trafficking in infection
Author(s) -
Metkar Shalaka,
Kim Kwang Sik,
Silver Jack,
Goyert Sanna M.
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0112011
Subject(s) - cd14 , biology , chemokine , cxcl2 , cxcl1 , immunology , microbiology and biotechnology , cxc chemokine receptors , sepsis , chemotaxis , inflammation , chemokine receptor , immune system , receptor , biochemistry
Harnessing the CD14‐independent pathway for chemokine induction in severe infection leads to early neutrophil recruitment to the site of infection, enhanced bacterial clearance, and survival.