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Reciprocal regulation of CXCR4 and CXCR7 in intestinal mucosal homeostasis and inflammatory bowel disease
Author(s) -
Werner Lael,
Elad Hofit,
Brazowski Eli,
Tulchinsky Hagit,
Vigodman Sharon,
Kopylov Uri,
Halpern Zamir,
GuznerGur Hanan,
Dotan Iris
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0111101
Subject(s) - cxcr4 , biology , inflammation , chemokine receptor , homeostasis , immunology , chemokine , intestinal mucosa , receptor , microbiology and biotechnology , cell migration , immune system , inflammatory bowel disease , cancer research , cell , disease , pathology , medicine , biochemistry , genetics
Differential regulation of CXCL12 receptors is suggested as mechanism to modulate T cells function in mucosal homeostasis and inflammation.