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Endotoxin‐induced uveitis is primarily dependent on radiation‐resistant cells and on MyD88 but not TRIF
Author(s) -
Kezic J.,
Taylor S.,
Gupta S.,
Planck S. R.,
Rosenzweig H. L.,
Rosenbaum J. T.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0111036
Subject(s) - trif , tlr4 , biology , lipopolysaccharide , inflammation , signal transduction , microbiology and biotechnology , immunology , toll like receptor , immune system , innate immune system
The anterior segment of the eye is especially sensitive to endotoxin and MyD88 pathway activation, but remarkably, the cells that are most sensitive are not bone marrow‐derived.