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N ‐Acylhomoserine lactones are potent neutrophil chemoattractants that act via calcium mobilization and actin remodeling
Author(s) -
Karlsson Thommie,
Musse Farah,
Magnusson KarlEric,
Vikström Elena
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0111034
Subject(s) - biology , chemotaxis , microbiology and biotechnology , cdc42 , calcium , cell migration , phosphorylation , calcium in biology , actin , pseudopodia , rac1 , rac gtp binding proteins , intracellular , signal transduction , biochemistry , cell , receptor , chemistry , organic chemistry
Human neutrophils migration towards N‐acylhomoserine lactone quorum sensing signaling molecules is associated with PLCγ and Rac1/Cdc42 phosphorylation, IP3R‐gated calcium release, and actin cytoskeleton reorganization.