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Developmental regulation of P‐glycoprotein activity within thymocytes results in increased anti‐HIV protease inhibitor activity
Author(s) -
Haraguchi Soichi,
Ho Sarah K.,
Morrow Matthew,
Goodenow Maureen M.,
Sleasman John W.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0111-009
Subject(s) - biology , thymocyte , cd8 , microbiology and biotechnology , protease , p glycoprotein , t cell , t lymphocyte , protease inhibitor (pharmacology) , viral replication , immunology , medicine , endocrinology , immune system , viral load , biochemistry , virus , enzyme , antiretroviral therapy , multiple drug resistance , antibiotics
P‐glycoprotein activity in the thymus provides a mechanism whereby protease inhibitors effectively suppress HIV‐1 replication in thymocytes