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Pivotal Advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19‐mediated adhesion of B cells in a PI3K‐dependent manner
Author(s) -
Lobo Elizabeth O.,
Zhang Zhifang,
Shively John E.
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0109037
Subject(s) - biology , breakpoint cluster region , cd19 , b cell , b cell receptor , tyrosine phosphorylation , syk , microbiology and biotechnology , cancer research , antibody , apoptosis , pi3k/akt/mtor pathway , signal transduction , flow cytometry , receptor , tyrosine kinase , immunology , biochemistry
CEACAM1 coreceptor for the B‐cell receptor inhibits activated B‐cells by recruiting SHP‐1 to its phosphorylated ITIMs, preventing phosphorylation of the large subunit of PI‐3K.