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Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells
Author(s) -
Bollyky Paul L.,
Falk Ben A.,
Wu Rebecca P.,
Buckner Jane H.,
Wight Thomas N.,
Nepom Gerald T.
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0109001
Subject(s) - biology , immune system , extracellular matrix , microbiology and biotechnology , foxp3 , cd44 , endogeny , homeostasis , function (biology) , inflammation , immune tolerance , immunology , matrix (chemical analysis) , signal transduction , cell , biochemistry , chemistry , chromatography
The authors describe the immunoregulatory contributions of intact versus fragmented hyaluronan, a prominent component of the extracellular matrix.
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