Premium
G‐protein‐coupled receptor expression, function, and signaling in macrophages
Author(s) -
Lattin Jane,
Zidar David A.,
Schroder Kate,
Kellie Stuart,
Hume David A.,
Sweet Matthew J.
Publication year - 2007
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0107051
Subject(s) - g protein coupled receptor , crosstalk , biology , signal transduction , macrophage , microbiology and biotechnology , receptor , inflammation , function (biology) , cell signaling , drug discovery , computational biology , bioinformatics , immunology , genetics , physics , optics , in vitro
G‐protein‐coupled receptors (GPCRs) are widely targeted in drug discovery. As macrophages are key cellular mediators of acute and chronic inflammation, we review here the role of GPCRs in regulating macrophage function, with a focus on contribution to disease pathology and potential therapeutic applications. Within this analysis, we highlight novel GPCRs with a macrophage‐restricted expression profile, which provide avenues for further exploration. We also review an emerging literature, which documents novel roles for GPCR signaling components in GPCR‐independent signaling in macrophages. In particular, we examine the crosstalk between GPCR and TLR signaling pathways and highlight GPCR signaling molecules which are likely to have uncharacterized functions in this cell lineage.