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In vivo rescue of defective memory CD8 + T cells by cognate helper T cells
Author(s) -
Kumaraguru Udayasankar,
Banerjee Kaustuv,
Rouse Barry T.
Publication year - 2005
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0105007
Subject(s) - biology , adoptive cell transfer , cytotoxic t cell , cd8 , immunology , immune system , t cell , microbiology and biotechnology , in vitro , genetics
The magnitude and efficacy of CD8 + T cell memory may notably regress, especially if immune induction occurs in the absence of adequate CD4 + help. This report demonstrates that this CD8 + memory malfunction could be remedied if a source of cognate antigen‐recognizing helper cells were provided during recall. The inability of adoptive transfer of memory SIINFEKL‐specific CD8 cells to reject tumors was overcome if recipients were primed for ovalbumin‐specific helper cell responses. Additionally, animals primed for a SIINFEKL‐specific memory response and incapable of rejecting the tumor could regain protective immunity if given helper cells. This pattern of CD8 + T cell functional rescue or reprogramming by helper cell transfer was replicated using a Herpes simplex virus antiviral immunity system. Our results could mean that therapeutic vaccine approaches could be designed to compensate situations that have defective CD8 + T cell function.