Open AccessParkinson's disease‐associated protein Parkin: an unusual player in cancer
Author(s) -
Liu Juan,
Zhang Cen,
Hu Wenwei,
Feng Zhaohui
Publication year - 2018
Publication title -
cancer communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 53
ISSN - 2523-3548
DOI - 10.1186/s40880-018-0314-z
Subject(s) - parkin , ubiquitin ligase , mitophagy , parkinson's disease , biology , carcinogenesis , ubiquitin , cancer , cancer research , mutation , disease , mechanism (biology) , reprogramming , genetics , microbiology and biotechnology , cell , apoptosis , gene , medicine , autophagy , philosophy , epistemology
The mutation of the Parkin gene is a cause of familial Parkinson's disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.