Open AccessTumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis
Author(s) -
Xie HongYan,
Shao ZhiMin,
Li DaQiang
Publication year - 2017
Publication title -
cancer communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 53
ISSN - 2523-3548
DOI - 10.1186/s40880-017-0202-y
Subject(s) - metastasis , tumor microenvironment , breast cancer , breast cancer metastasis , cancer , cancer metastasis , cancer research , mechanism (biology) , medicine , disease , philosophy , epistemology
Distant metastasis to specific target organs is responsible for over 90% of breast cancer‐related deaths, but the underlying molecular mechanism is unclear. Mounting evidence suggests that the interplay between breast cancer cells and the target organ microenvironment is the key determinant of organ‐specific metastasis of this lethal disease. Here, we highlight new findings and concepts concerning the emerging role of the tumor microenvironment in breast cancer metastasis; we also discuss potential therapeutic intervention strategies aimed at targeting components of the tumor microenvironment.