Open AccessOverweight/obese status associates with favorable outcome in patients with metastatic nasopharyngeal carcinoma: a 10‐year retrospective study
Author(s) -
Li Wang,
Shen LuJun,
Chen Tao,
Sun XuQi,
Zhang Ying,
Wu Ming,
Shu WanHong,
Chen Chen,
Pan ChangChuan,
Xia YunFei,
Wu PeiHong
Publication year - 2016
Publication title -
cancer communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 53
ISSN - 2523-3548
DOI - 10.1186/s40880-016-0139-6
Subject(s) - underweight , medicine , overweight , body mass index , hazard ratio , nasopharyngeal carcinoma , multivariate analysis , confidence interval , proportional hazards model , retrospective cohort study , obesity , oncology , radiation therapy
Background Although the prognostic impact of body mass index (BMI) in patients with non‐metastatic nasopharyngeal carcinoma (NPC) had been extensively studied, its effect among metastatic NPC patients remains unknown. The purpose of this study was to evaluate the prognostic effect of BMI in patients with metastatic NPC. Methods We retrospectively studied 819 patients who were diagnosed with distant metastasis from NPC and received treatment between 1998 and 2007. The patients were divided into three subgroups according to the World Health Organization classifications for Asian populations: underweight (BMI <18.5 kg/m 2 ), normal weight (BMI 18.5–22.9 kg/m 2 ), and overweight/obese (BMI ≥23.0 kg/m 2 ). The associations of BMI with overall survival (OS) and progression‐free survival (PFS) were determined by Cox regression analysis. Results Of the 819 patients, 168 (20.5%) were underweight, 431 (52.6%) were normal weight, and 220 (26.9%) were overweight/obese. Multivariate analysis adjusted for covariates showed that overweight/obese patients had a longer OS than underweight patients [hazard ratio (HR), 0.64; 95% confidence interval (CI), 0.49–0.84] and normal weight patients (HR, 0.72; 95% CI, 0.57–0.90); no significant difference in PFS was observed among these three groups ( P = 0.407). Moreover, in stratified analysis, no statistically significant differences in the effect of overweight/obese status among different subgroups were observed. Conclusion For patients with metastatic NPC, overweight/obese status was associated with longer OS but not longer PFS compared with underweight or normal weight status.