Open AccessAssociation of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case–control study
Author(s) -
Miao Limin,
Wang Lihua,
Zhu Longbiao,
Du Jiangbo,
Zhu Xun,
Niu Yuming,
Wang Ruixia,
Hu Zhibin,
Chen Ning,
Shen Hongbing,
Ma Hongxia
Publication year - 2016
Publication title -
cancer communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 53
ISSN - 2523-3548
DOI - 10.1186/s40880-016-0136-9
Subject(s) - head and neck squamous cell carcinoma , odds ratio , single nucleotide polymorphism , oncology , case control study , confidence interval , medicine , genetic model , allele , population , microrna , head and neck cancer , cancer , genotype , biology , bioinformatics , genetics , gene , environmental health
Background MicroRNA (miRNA) polymorphisms may alter miRNA‐related processes, and they likely contribute to cancer susceptibility. Various studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers; however, few studies have focused on head and neck squamous cell carcinoma (HNSCC) risk. This study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese population. Methods In this study, we genotyped five common single‐nucleotide polymorphisms (SNPs) in several key miRNAs ( miR ‐ 149 rs2292832, miR ‐ 146a rs2910164, miR ‐ 605 rs2043556, miR ‐ 608 rs4919510, and miR ‐ 196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case–control study including 576 cases and 1552 controls, which were matched by age and sex in a Chinese population. Results The results revealed that miR ‐ 605 rs2043556 [dominant model: adjusted odds ratio (OR) 0.71, 95% confidence interval (CI) 0.58–0.88; additive model: adjusted OR 0.74, 95% CI 0.62–0.89] and miR ‐ 196a2 rs11614913 (dominant model: adjusted OR 1.36, 95% CI 1.08–1.72; additive model: adjusted OR 1.28, 95% CI 1.10–1.48) were significantly associated with the risk of oral squamous cell carcinoma (OSCC). Furthermore, when these two loci were evaluated together based on the number of putative risk alleles (rs2043556 A and rs11614913 G), a significant locus‐dosage effect was noted on the risk of OSCC ( P trend < 0.001). However, no significant association was detected between the other three SNPs ( miR ‐ 149 rs2292832, miR ‐ 146a rs2910164, and miR ‐ 608 rs4919510) and HNSCC risk. Conclusion Our study provided the evidence that miR ‐ 605 rs2043556 and miR ‐ 196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population.