Open AccessMechanisms of vascularization in murine models of primary and metastatic tumor growth
Author(s) -
Bugyik Edina,
RenyiVamos Ferenc,
Szabo Vanessza,
Dezso Katalin,
Ecker Nora,
Rokusz Andras,
Nagy Peter,
Dome Balazs,
Paku Sandor
Publication year - 2016
Publication title -
cancer communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 53
ISSN - 2523-3548
DOI - 10.1186/s40880-016-0083-5
Subject(s) - angiogenesis , primary tumor , pathology , sprouting angiogenesis , medicine , metastasis , tumor cells , neovascularization , microcirculation , mechanism (biology) , cancer research , cancer , philosophy , epistemology
Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanisms, such as intussusceptive microvascular growth, vessel co‐option, and glomeruloid angiogenesis. Importantly, in response to anti‐angiogenic therapies, malignant tumors can switch from one vascularization mechanism to another. In this article, we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology.