Open AccessRevisiting tumor angiogenesis: vessel co‐option, vessel remodeling, and cancer cell‐derived vasculature formation
Author(s) -
Qian ChaoNan,
Tan MinHan,
Yang JunPing,
Cao Yun
Publication year - 2016
Publication title -
cancer communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 53
ISSN - 2523-3548
DOI - 10.1186/s40880-015-0070-2
Subject(s) - angiogenesis , sprouting angiogenesis , metastasis , cancer research , neovascularization , vascular endothelial growth factor , tumor microenvironment , cancer , progenitor cell , biology , medicine , microbiology and biotechnology , tumor cells , stem cell , vegf receptors
Tumor growth and metastasis depend on the establishment of tumor vasculature to provide oxygen, nutrients, and other essential factors. The well‐known vascular endothelial growth factor (VEGF) signaling is crucial for sprouting angiogenesis as well as recruitment of circulating progenitor endothelial cells to tumor vasculature, which has become therapeutic targets in clinical practice. However, the survival benefits gained from targeting VEGF signaling have been very limited, with the inevitable development of treatment resistance. In this article, we discuss the most recent findings and understanding on how solid tumors evade VEGF‐targeted therapy, with a special focus on vessel co‐option, vessel remodeling, and tumor cell‐derived vasculature establishment. Vessel co‐option may occur in tumors independently of sprouting angiogenesis, and sprouting angiogenesis is not always required for tumor growth. The differences between vessel‐like structure and tubule‐like structure formed by tumor cells are also introduced. The exploration of the underlying mechanisms of these alternative angiogenic approaches would not only widen our knowledge of tumor angiogenesis but also provide novel therapeutic targets for better controlling cancer growth and metastasis.