Open AccessPrognostic role of the ABO blood types in Chinese patients with curatively resected non‐small cell lung cancer: a retrospective analysis of 1601 cases at a single cancer center
Author(s) -
Li Ning,
Xu Miao,
Li ChaoFeng,
Ou Wei,
Wang BaoXiao,
Zhang SongLiang,
Xu PengFei,
Yuan Cheng,
Huang QunAi,
Wang SiYu
Publication year - 2015
Publication title -
cancer communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 53
ISSN - 2523-3548
DOI - 10.1186/s40880-015-0054-2
Subject(s) - medicine , abo blood group system , hazard ratio , lung cancer , single center , univariate analysis , blood type (non human) , gastroenterology , oncology , cancer , confidence interval , surgery , multivariate analysis
Background A positive association between the ABO blood types and survival has been suggested in several malignancies. The aim of this study was to assess the role of the ABO blood types in predicting the prognosis of Chinese patients with curatively resected non‐small cell lung cancer (NSCLC). Methods We retrospectively analyzed 1601 consecutive Chinese patients who underwent curative surgery for NSCLC between January 1, 2005 and December 31, 2009. The relationship between the ABO blood types and survival was investigated. In addition, univariate and multivariate analyses were performed. Results Group 1 (patients with the blood type O or B) had significantly prolonged overall survival (OS) compared with group 2 (patients with the blood type A or AB), with a median OS of 74.9 months versus 61.5 months [hazard ratio (HR) 0.83; 95% confidence interval (CI) 0.72–0.96; P = 0.015]. Additionally, group 1 had significantly longer disease‐free survival (DFS; HR 0.86; 95% CI 0.76–0.98; P = 0.022) and locoregional relapse‐free survival (LRFS; HR 0.79; 95% CI 0.64–0.98; P = 0.024) than group 2. The association was not significantly modified by other risk factors for NSCLC, including smoking status, pathologic tumor‐node‐metastasis stage, pT category, pN category, and chemotherapy. Conclusions There is an association between the ABO blood types and the survival of Chinese patients with resected NSCLC. Patients with the blood type O or B had significantly prolonged OS, DFS, and LRFS compared with those with the blood type A or AB.