Open AccessWnt3a: functions and implications in cancer
Author(s) -
He Sha,
Lu Yi,
Liu Xia,
Huang Xin,
Keller Evan T.,
Qian ChaoNan,
Zhang Jian
Publication year - 2015
Publication title -
cancer communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.119
H-Index - 53
ISSN - 2523-3548
DOI - 10.1186/s40880-015-0052-4
Subject(s) - wnt3a , wnt signaling pathway , motility , cancer research , biology , microbiology and biotechnology , signal transduction , cancer , genetics
Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self‐renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer.