Open AccessPhysical, morphological, and wound healing properties of a polyurethane foam-film dressing
Author(s) -
Seung Moon Lee,
Il Kyu Park,
Yong Soo Kim,
Hyun Jung Kim,
Hanlim Moon,
Stefan Müeller,
YoungIl Jeong
Publication year - 2016
Publication title -
biomaterials research/biomaterials research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.604
H-Index - 24
eISSN - 2055-7124
pISSN - 1226-4601
DOI - 10.1186/s40824-016-0063-5
Subject(s) - polyurethane , ultimate tensile strength , materials science , composite material , wound healing , simulated body fluid , absorption (acoustics) , scanning electron microscope , biomedical engineering , absorption of water , contact angle , surgery , medicine
Background We investigated the physicochemical properties of Medifoam® N and its wound healing performance compared to other commercially available polyurethane (PU) foam dressing in vitro and in vivo to gain insight in their clinical performance. Methods Wound contact layer and cross-section of eleven polyurethane foam dressings were assessed with field-emission scanning electron microscope. Thickness, density, tensile strength, elongation, moisture-vapor transmission rate (MVTR), retention and absorptivity were measured to compare physical properties. Phosphate-buffered saline (PBS) solution absorption patterns were compared. An animal model for wound-healing was applied to validate in vitro findings. Results Among eleven tested foam dressings, Medifoam® N has the smallest pore and cell sizes with excellent uniformity, i.e. it has 25 ~ 75 μm on the wound contact layer and 100 ~ 350 μm in the cross-section while other dressings have a larger pose size with larger variability. Compared to other PU foams, Medifoam® N also has moderate thickness, density, tensile strength, elongation and MVTR. Furthermore, it has excellent fluid absorption and retention capacity. These intrinsic properties of Medifoam® N contributed to improve fluid absorption patterns, i.e. other dressing material flawed out PBS solution on the dressings while Medifoam® N retained all the tested solutions. In animal wound-healing study, Medifoam® N treated animals showed excellent angiogenesis and collagen deposition even though epithelial recovery rate was not significantly different to other dressings. Conclusions Medifoam® N has optimized physical properties and thus improved fluid absorption/retention capacity. Compared to other dressings, Medifoam® N showed excellent fluid absorption patterns and these characteristics contributed to improved wound healing and excellent angiogenic potential. We found that Medifoam® N showed the best results among the employed dressing samples. Electronic supplementary material The online version of this article (doi:10.1186/s40824-016-0063-5) contains supplementary material, which is available to authorized users.