Open AccessEpigenetics of hepatocellular carcinoma
Author(s) -
Toh Tan Boon,
Lim Jhin Jieh,
Chow Edward KaiHua
Publication year - 2019
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1186/s40169-019-0230-0
Subject(s) - epigenetics , hepatocellular carcinoma , liver cancer , carcinogenesis , genomics , cancer , genome , disease , medicine , bioinformatics , computational biology , biology , cancer research , pathology , genetics , gene
Abstract In recent years, large scale genomics and genome‐wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity. Hepatocellular carcinoma, being one of the most deadly cancers in the world has been well established as a disease of the genome that harbours a multitude of genetic and epigenetic aberrations during the process of liver carcinogenesis. As such, in depth understanding of the cancer epigenetics in cancer specimens and biopsy can be useful in clinical settings for molecular subclassification, prognosis, and prediction of therapeutic responses. In this review, we present a concise discussion on recent progress in the field of liver cancer epigenetics and some of the current works that contribute to the progress of liver cancer therapeutics.