Open AccessMechanoregulation and pathology of YAP/TAZ via Hippo and non‐Hippo mechanisms
Author(s) -
Dobrokhotov Oleg,
Samsonov Mikhail,
Sokabe Masahiro,
Hirata Hiroaki
Publication year - 2018
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1186/s40169-018-0202-9
Subject(s) - hippo signaling pathway , medicine , microbiology and biotechnology , biology , signal transduction
Abstract Yes‐associated protein (YAP) and its paralog WW domain containing transcription regulator 1 (TAZ) are important regulators of multiple cellular functions such as proliferation, differentiation, and survival. On the tissue level, YAP/TAZ are essential for embryonic development, organ size control and regeneration, while their deregulation leads to carcinogenesis or other diseases. As an underlying principle for YAP/TAZ‐mediated regulation of biological functions, a growing body of research reveals that YAP/TAZ play a central role in delivering information of mechanical environments surrounding cells to the nucleus transcriptional machinery. In this review, we discuss mechanical cue‐dependent regulatory mechanisms for YAP/TAZ functions, as well as their clinical significance in cancer progression and treatment.