Open AccessPrecision medicine in immune checkpoint blockade therapy for non‐small cell lung cancer
Author(s) -
Liu Xiaoming,
Cho William C.
Publication year - 2017
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1186/s40169-017-0136-7
Subject(s) - blockade , immune checkpoint , medicine , lung cancer , immune system , precision medicine , targeted therapy , pd l1 , tumor microenvironment , companion diagnostic , cancer research , antibody , cancer , immunotherapy , oncology , immunology , pathology , receptor
Immune checkpoint blockade therapy by targeting the programmed death protein 1/programmed death ligand 1 (PD‐L1) axis using antibodies has yielded promising clinical responses in patients with non‐small cell lung cancer (NSCLC). However, owing to the dynamic expression of PD‐L1, degree of mutational/neoantigen load, intratumoral heterogeneity, infiltrated immune cells of tumor microenvironment of NSCLC, the response rates to these agents are limited, despite several companion diagnostic assays by detecting PD‐L1 in tumor cells have been introduced into clinical practice. Therefore, in this era of precision medicine, there is an urgent need for predictive biomarkers to identify NSCLC patients likely to benefit from this novel therapy.