Open AccessPrognostic factors in the acute respiratory distress syndrome
Author(s) -
Chen Wei,
Ware Lorraine B
Publication year - 2015
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1186/s40169-015-0065-2
Subject(s) - ards , medicine , intensive care medicine , acute respiratory distress , risk stratification , clinical trial , psychological intervention , lung , psychiatry
Despite improvements in critical care, acute respiratory distress syndrome (ARDS) remains a devastating clinical problem with high rates of morbidity and mortality. A better understanding of the prognostic factors associated with ARDS is crucial for facilitating risk stratification and developing new therapeutic interventions that aim to improve clinical outcomes. In this article, we present an up‐to‐date summary of factors that predict mortality in ARDS in four categories: (1) clinical characteristics; (2) physiological parameters and oxygenation; (3) genetic polymorphisms and biomarkers; and (4) scoring systems. In addition, we discuss how a better understanding of clinical and basic pathogenic mechanisms can help to inform prognostication, decision‐making, risk stratification, treatment selection, and improve study design for clinical trials.