Open AccessUnravelling the expression of interleukin‐9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus
Author(s) -
Delemarre Tim,
De Ruyck Natalie,
Holtappels Gabriele,
Bachert Claus,
Gevaert Elien
Publication year - 2020
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/s13601-020-00348-5
Subject(s) - medicine , staphylococcus aureus , immunology , allergy , cytokine , asthma , enterotoxin , superantigen , nasal polyps , copd , inflammation , interleukin , immune system , bacteria , t cell , biology , biochemistry , genetics , escherichia coli , gene
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a Th2 biased inflammation, associated with nasal colonization of Staphylococcus ( S. ) aureus . Interleukin (IL)‐9 is a pro‐inflammatory Th2 cytokine with a pivotal role in asthma, allergy and chronic obstructive pulmonary disease (COPD), but is less studied in CRSwNP. We aimed to characterize the expression and cellular source of IL‐9 and examined S. aureus as potential local trigger in CRSwNP. We showed increased numbers of interleukin‐9 producing neutrophils and mononuclear cells in the tissue of CRSwNP patients. This interleukin‐9 production was stimulated by S. aureus and its enterotoxin B in vitro. These findings underline the contribution of S. aureus and define IL‐9 as another relevant cytokine in type 2 CRSwNP.