Open AccessHistamine H4 receptor regulates IL‐6 and INF‐γ secretion in native monocytes from healthy subjects and patients with allergic rhinitis
Author(s) -
Peng Hua,
Wang Jian,
Ye Xiao Yan,
Cheng Jie,
Huang Cheng Zhi,
Li Li Yue,
Li Tian Ying,
Li Chun Wei
Publication year - 2019
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/s13601-019-0288-1
Subject(s) - histamine , medicine , histamine h4 receptor , secretion , allergy , immunology , histamine h1 receptor , house dust mite , allergen , receptor , allergic inflammation , histamine receptor , monocyte , histamine h2 receptor , antagonist , pharmacology
Histamine H1 receptor (H1R) and histamine H4 receptor (H4R) are essential in allergic inflammation. The roles of H4R have been characterized in T cell subsets, whereas the functional properties of H4R in monocytes remain unclear. In the current study, the responses of H4R in peripheral monocytes from patients with allergic rhinitis (AR) were investigated. The results confirmed that H4R has the functional effects of mediating cytokine production (i.e., down‐regulating IFN‐γ and up‐regulating IL‐6) in cells from a monocyte cell line following challenge with histamine. We demonstrated that when monocytes from AR patients were stimulated with allergen extracts of house dust mite (HDM), IFN‐γ secretion was dependent on H4R activity, but IL‐6 secretion was based on H1R activity. Furthermore, a combination of H1R and H4R antagonists was more effective at blocking the inflammatory response in monocytes than treatment with either type of antagonist alone.