Open AccessThe prevalence of asthma in adult population of southwestern Iran and its association with chronic rhinosinusitis: a GA 2 LEN study
Author(s) -
Ostovar Afshin,
Fokkens Wytske J.,
Pordel Safoora,
Movahed Ali,
Ghasemi Khadijeh,
Marzban Maryam,
Farrokhi Shokrollah
Publication year - 2019
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/s13601-019-0283-6
Subject(s) - medicine , asthma , logistic regression , population , chronic rhinosinusitis , allergy , cross sectional study , public health , demography , pediatrics , environmental health , immunology , pathology , sociology
Background Asthma is recognized as a major public health concern in the world. The aim of this investigation was to evaluate the prevalence of asthma by using the Global Allergy and Asthma Network of Excellence (GA 2 LEN) questionnaire and examine its association with chronic rhinosinusitis, in the province of Bushehr, Southwestern of Iran. Methods In a cross‐sectional, population‐based study, a total of 5420 invited individuals, aged 15–65, were selected through a multi‐stage, stratified, cluster random sampling and from which 5201 completed the GA 2 LEN questionnaire (response rate = 95.9%). The prevalence of asthma, current, and physician‐diagnosed asthma were analyzed by using sex and age groups and the association of asthma and chronic rhinosinusitis (CRS) was investigated using a multiple logistic regression model. Results Based on the information from the GA 2 LEN questionnaire, the overall prevalence of asthma in the population under study was 10.0% (95% CI 9.2–10.8). Moreover, the prevalence of current asthma was 8.9% (95% CI 8.1–9.7). Further, the prevalence of current early, late‐onset and physician‐diagnosed asthma within the asthma group was 51.1% (95% CI 46.5–55.7), 48.9% (95% CI 44.3–53.5) and 3.9% (95% CI 2.1–2.5), respectively. Additionally, CRS was more frequent among the participants with asthma [(57.3%, OR = 2.3; 95% CI 2.1–2.5)], and there was a significant association between CRS and current, early and late‐onset of asthma (P < 0.001; OR = 4.4, 3.2 and 6, respectively). Conclusion This large population study conducted in the southwestern part of Iran suggests that the prevalence of asthma is high. Moreover, the result of this study showed a strong association of asthma with CRS; also after adjusting for sex, age, educational level, and smoking.