Open AccessHigh occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
Author(s) -
Hofman Zonne L. M.,
West Nikki,
Hack C. Erik,
Knulst André C.,
Maas Coen,
Röckmann Heike
Publication year - 2019
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/s13601-019-0274-7
Subject(s) - antihistamine , medicine , angioedema , refractory (planetary science) , dermatology , allergy , incidence (geometry) , anesthesia , immunology , physics , astrobiology , optics
Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36%) of antihistamine refractory cases was observed. Forty percent of patients on antihistamine prophylaxis suffered from 1 or more angioedema attacks per month. Our findings stress the need for additional treatment options for recurrent idiopathic angioedema.