Open AccessInnate lymphocyte cells in asthma phenotypes
Author(s) -
Ozyigit Leyla Pur,
Morita Hideaki,
Akdis Mubeccel
Publication year - 2015
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/s13601-015-0068-5
Subject(s) - medicine , asthma , phenotype , immunology , allergy , lymphocyte , innate lymphoid cell , allergic asthma , innate immune system , immune system , genetics , biology , gene
T helper type 2 (T H 2) cells were previously thought to be the main initiating effector cell type in asthma; however, exaggerated T H 2 cell activities alone were insufficient to explain all aspects of asthma. Asthma is a heterogeneous syndrome comprising different phenotypes that are characterized by their different clinical features, treatment responses, and inflammation patterns. The most‐studied subgroups of asthma include T H 2‐associated early‐onset allergic asthma, late‐onset persistent eosinophilic asthma, virus‐induced asthma, obesity‐related asthma, and neutrophilic asthma. The recent discovery of human innate lymphoid cells capable of rapidly producing large amounts of cytokines upon activation and the mouse data pointing to an essential role for these cells in asthma models have emphasized the important role of the innate immune system in asthma and have provided a new means of better understanding asthma mechanisms and differentiating its phenotypes.