
Cold agglutinin-induced hemolytic anemia during room temperature fluid resuscitation: a case report
Author(s) -
Yosuke Kawai,
Miyoshi Deguchi,
Naoko Mizouchi,
Shigeo Yoshida,
Ken Kumagai,
Yasuo Hirose
Publication year - 2021
Publication title -
journal of medical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.287
H-Index - 31
ISSN - 1752-1947
DOI - 10.1186/s13256-021-02784-8
Subject(s) - cold agglutinin disease , medicine , cold agglutinin , hemolytic anemia , diabetic ketoacidosis , resuscitation , anemia , autoimmune hemolytic anemia , coombs test , agglutination (biology) , anesthesia , immunology , insulin , antibody
Background Cold agglutinin disease can cause the agglutination of red blood cells and hemolytic anemia due to cold temperature. Herein, we report a case of progressive hemolytic anemia due to cold agglutinin disease during fluid resuscitation and in the absence of exposure to cold. Case presentation A 71-year-old Japanese man was admitted to the emergency department with signs of hypotension and disturbed consciousness. He was diagnosed with diabetic ketoacidosis, and treatment with fluid resuscitation and insulin infusion was initiated. Laboratory test results obtained the following day indicated hemolytic anemia. On day 5 after admission, red blood cell agglutination was detected, and the patient was diagnosed with cold agglutinin disease. Conclusions Cold agglutinin disease should be considered in the differential diagnosis of progressive hemolytic anemia during fluid resuscitation, even if the solution is at room temperature.