Open AccessFirst experiences with cough sensitivity in model of allergic rhinitis induced in HDM‐sensitized guinea pigs
Author(s) -
Buday Tomas,
Gavliakova Silvia,
Kovacova Eva,
Mokry Juraj,
Medvedova Ivana,
Plevkova Jana
Publication year - 2015
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-5-s4-p8
Subject(s) - medicine , ovalbumin , allergy , sensitization , immunology , allergen , nasal administration , inhalation , antigen , anesthesia
Background Nowadays, the vast majority of research focusing on cough in sensitive and/or hyperreactive airways is done on an animal model of guinea pigs intraperitoneally sensitized by ovalbumin. There are no objections to model animal – the neurophysiology and neuropharmacology of their n. X are closest to humans. However, the choice of ovalbumin as model antigen together with the route of administration remains questionable – allergy to chicken eggs in humans manifests as food allergy, not respiratory allergy. These limitations may represent possible obstacles in translation of results in daily clinical practice. Therefore there is need to develop and validate new model of airway hypersensitivity, which would simulate real-life conditions more closely and new model could improve translation of results. Most important indoor allergen for people are house dust mites (HDM), most common species being D. pteronyssius and D. farinae. Their allergenic potential is complex – it includes immunogenic epitopes, faecal pellets, lipopolysaccharides, betaglucans and chitin.