Open AccessConverging evidence for the pro‐inflammatory role of p‐glycoprotein in Th2 polarized chronic rhinosinusitis endotypes
Author(s) -
Bleier Benjamin
Publication year - 2015
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-5-s4-p7
Subject(s) - nasal polyps , medicine , immunology , secretion , inflammation , cytokine , p glycoprotein , eosinophilia , biology , antibiotics , microbiology and biotechnology , multiple drug resistance
Background T-helper 2 (Th2) inflammation is a hallmark of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) and eosinophilic CRS (eCRS) although the pathogenesis is poorly understood. P-glycoprotein (P-gp) is an efflux pump which is expressed within sinonasal mucosa and is capable of regulating cytokine transport in both epithelial and T-cells. The purpose of this study was to synthesize multiple lines of evidence suggesting that P-gp may promote inflammation in Th2 polarized CRS endotypes.