Open AccessA role for neuropeptides in innate immune inflammation of the nose
Author(s) -
Larsson Olivia,
Tengroth Lotta,
Xu Yuan,
Georen Susanna Kumlien,
Cardell LarsOlaf
Publication year - 2015
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-5-s4-o2
Subject(s) - substance p , medicine , toll like receptor , tlr7 , stimulation , receptor , immune system , inflammation , tlr2 , immunology , neuropeptide , tachykinin receptor 1 , innate immune system , allergy , pharmacology , neurokinin a
Background The airway epithelium constitutes the first line of defense in the protection against invading pathogens. It acts as a barrier, but it is also is a major source of early released inflammatory mediators, which help shape the inflammatory response. Neuropeptides, such as substance P (SP), have long been considered to be early contributors to the inflammatory response, causing pain hypersensitivity and vasodilation, as well as activation and infiltration of various immune cells. Toll-like receptor 7 (TLR7) is found on the epithelial cells and is known to be activated by viruses. The present study has investigated the relationship between TLR7 activation/expression and SP release/ stimulation.