Open AccessA larger study of food‐related IgG confirms the possible new epidemiological approach to non‐IgE‐mediated reactions and suggests five great food clusters
Author(s) -
Speciani Francesco Attilio,
Piuri Gabriele,
Soriano Jacopo,
Ferrazzi Enrico
Publication year - 2015
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-5-s3-p39
Subject(s) - immunoglobulin e , antigen , food allergy , immunology , medicine , antibody , receptor , allergy , biology
Background Studies in mouse models show 2 pathways of systemic anaphylaxis: the classic one mediated by IgE, FceRI, mast cells and histamine and platelet-activating factor (PAF) and the alternative way mediated by total IgG, FcgRIII, macrophages, and PAF. The importance of the latter in humans is still uncertain, but human IgG, IgG receptors, macrophages, mediators and their receptors have appropriate properties to support this pathway if enough IgG and antigens are present [1]. Food specific IgG values might reflect the exposure to food clusters in individual diet habits [2]. This suggests new perspectives in understanding non-IgE-related reactions. The aim of this perspective study was to assess the robustness of food antigen cluster analysis [3] on a larger cohort of subjects.