Open AccessRETRACTED ARTICLE: Partially hydrolysed, prebiotic supplemented whey formula for the prevention of allergic manifestations in high risk infants: a multicentre double‐blind randomised controlled trial
Author(s) -
Boyle Robert,
Brown Nick,
Chiang Wen Chin,
Chien Chua Mei,
Gold Michael,
Hourihane Jonathan,
Peake Jane,
Quinn Patrick,
Rao Raj,
Smith Peter,
Tang Mimi,
Ziegler John,
Warner John
Publication year - 2015
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-5-s3-p30
Subject(s) - medicine , infant formula , breastfeeding , prebiotic , pediatrics , allergy , atopic dermatitis , randomized controlled trial , milk allergy , incidence (geometry) , food allergy , immunology , food science , chemistry , physics , optics
[95%CI 0.65-1.36]). We found no difference in AM at 3-5 years. The active group had lower serum cow’s milk (CM) IgG1 at 6 months than the control (p<0.0001) and this difference was still observed at 3 years (p=0.007). Higher CM-IgG1 levels at 6 months were significantly associated with development of specific IgE (CM, hen’s egg) at 3 years (p<0.05). We found no difference between groups in adverse events. Post-hoc analyses were performed on infants who had not introduced solids < 18 weeks (n=312). In this subgroup, active formula was associated with reduced AM at 3-5 years (n=144; p=0.0334) and lower levels of total-IgE and hen’s egg IgE at 6 months (n=239, p=0.0092 and n=244, p=0.0061) compared with control group.