Open AccessAcute tryptase determinations in NSAID‐induced anaphylaxis: could we avoid drug challenges?
Author(s) -
Arroabarren Esozia,
Rodriguez Antonio,
Olaguibel Jose Maria,
Garcia Blanca,
Aldunate Maria Teresa,
AlvarezPuebla Maria,
Garrido Sara,
Echechipía Susana,
Lizaso Maria Teresa,
Anda Marta,
Gomez Belen,
Tabar Ana
Publication year - 2015
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-5-s3-p144
Subject(s) - medicine , tryptase , anaphylaxis , gastroenterology , angioedema , allergy , metamizole , group b , group a , demographics , anesthesia , analgesic , immunology , mast cell , demography , sociology
Methods Retrospective review of patients attending the Emergency Department (2009-2013) for a NSAID induced anaphylaxis and with a tryptase determination. Patients were split into 3 groups according to the allergy workup Results Selective reactions (S) were defined by positive skin results and/or negative challenges with other NSAID; non-selective (NS) reactions were defined by the existence of symptoms with several NSAID or after positive challenge results. Those cases who did not comply with the previous conditions were non-conclusive (NC). We analysed: demographics, severity of the episode (Chi Square test), and rate of tryptase higher than 11.4 mcg/l (Chi Square test), median tryptase values and timing of sample obtention (Kruskall-Wallis).