Open AccessIncreased tryptase in children with allergic reactions to hazelnut
Author(s) -
Brändström Josef,
Uppsten Rydell Niclas,
Sjölander Anders,
Nilsson Caroline
Publication year - 2015
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-5-s3-p108
Subject(s) - tryptase , medicine , mast cell , immunology , allergy , placebo , anaphylactic reactions , anaphylaxis , pathology , alternative medicine
Background Mast cells are activated during allergic reactions, releasing inflammatory mediators that include tryptase. This process leads to the symptoms of an allergic reaction. A transient increase in the total level of serum tryptase indicates mast cell activation, e.g. an anaphylactic reaction. This may help to confirm and assess the extent of a systemic reaction. In the current study, the total level of serum tryptase was measured at different time points; before, during and after double-blind placebo-controlled food challenge (DBPCFC) with hazelnut in 40 suspected hazelnut allergic children aged 6-18 years. Total serum tryptase was measured with ImmunoCAP Tryptase, Thermo Fisher Scientific, Uppsala, Sweden.