Open AccessThe use of aluminum hydroxide as adjuvant modulates the antibody response to food allergens
Author(s) -
Bøgh Katrine Lindholm,
Andreasen Mie Scharff,
Madsen Charlotte Bernhard
Publication year - 2015
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-5-s3-p100
Subject(s) - epitope , adjuvant , conformational epitope , antibody , allergen , milk allergy , denaturation (fissile materials) , immunoglobulin e , allergy , immunology , medicine , chemistry , nuclear chemistry
Background Aluminum hydroxide (Al(OH)3) is a widely used adjuvant for induction of experimentally Th2 responses in animals and hence has been used for examination of food protein allergenicity. Further Al(OH)3 is used as an adjuvant for subcutaneous allergy vaccines. In the present study we investigated the impact of the use of Al(OH)3 on the antibody specificity to the cow’s milk allergens b-lactoglobulin and a-lactalbumin.