Open AccessCarbimazole induced acute generalised exanthematous pustulosis
Author(s) -
Kadambi Madhavi,
K M santhosh,
BV Murali mohan,
Syed Tousheed
Publication year - 2015
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-5-s1-p16
Subject(s) - medicine , carbimazole , dermatology , acute generalized exanthematous pustulosis , drug eruption , drug , pharmacology , thyroid , graves' disease
Background Acute generalised exanthematous pustulosis (AGEP) also known as pustular drug eruption is an unusual drug induced hypersensitivity skin manifestation, characterized by acute onset of fever, and numerous non-follicular pinhead sterile pustules on erythematous background , usually over the flexural areas and face [1]. Neutrophils are involved in the pathogenesis of AGEP. Neutrophilactivating cytokines like IL-3 and IL-8 have been implicated [2]. Around 90 percent of the times AGEP is caused by a drug. Reported most often due to antibacterials. Carbimazole which is a thiourea antithyroid drug is not one of the usual suspect.