Open AccessHLA association with antipyretic analgesics‐induced Stevens‐Johnson Syndrome/toxic epidermal necrolysis with severe ocular surface complications in japanese patients
Author(s) -
Nakamura Ryosuke,
Kaniwa Nahoko,
Ueta Mayumi,
Sotozono Chie,
Sugiyama Emiko,
Maekawa Keiko,
Yagami Akiko,
Matsukura Setsuko,
Ikezawa Zenro,
Matsunaga Kayoko,
Tokunaga Katsushi,
Aihara Michiko,
Kinoshita Shigeru,
Saito Yoshiro
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p89
Subject(s) - toxic epidermal necrolysis , medicine , dermatology , antipyretic , adverse effect , drug , gastroenterology , anesthesia , analgesic , pharmacology
Background Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are severe adverse drug reactions which are very rare, acute, serious, and potentially fatal. They exhibit characteristic symptoms not only in the skin, but also in the mucosal tissues such as ocular surface, oral cavity, and genitals. Although antipyretic analgesics (AAs) are some of the most frequent causative drugs of SJS/TEN, there has been no HLA association studies on these drugs-induced SJS/TEN. The scope of this study is to investigate HLA-type association with AA-related SJS/TEN with severe ocular surface complications (SOCs). Method