Open AccessColloidal silica‐induced hypersensitivity: myth or reality topics: clinical cases/case series: non‐immediate elayed T cells IgG
Author(s) -
Fredj Nadia Ben,
Fadhel Najeh Ben,
Chadly Zohra,
Boughattas Naceur,
Aouam Karim,
Chaabane Amel
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p79
Subject(s) - medicine , ketoprofen , patch test , piroxicam , pharmacology , diclofenac , dermatology , allergy , immunology , pathology , alternative medicine
Background Colloidal silica is an inorganic substance widely used as excipient in pharmaceutical preparation. It acts as a vehicule to increase the absorption of many oral drug formulations. Many excipients have been reported to induce drug hypersensitivity such as tartrazine, aspartame, benzalkonium chloride, sodium metabisulphite, propyl gallate. However, colloidal silica has never been reported to induce hypersensitivity. We report herein a case of colloidal silica-induced hypersensitivity confirmed by a positive patch test.