Open AccessEffectiveness of premedication for hypersensitivity reactions to radiocontrast media in one tertiary hospital
Author(s) -
Jung JaeWoo,
Kang HyeRyun,
Choi ByoungWhui
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p74
Subject(s) - premedication , medicine , angioedema , hypersensitivity reaction , rash , anesthesia , itching , incidence (geometry) , allergy , delayed hypersensitivity , dermatology , surgery , immunology , physics , antigen , optics
Results A total of 401 patients with a history of hypersensitivity reaction to RCM and were premedicated at re-exposure to RCM. Male was 177 (44.1%) and mean age was 55.83i¾11.92 years. Most common hypersensitivity symptom was urticaria (259, 64.6%), followed by itching (36.7%), rash (21.4%) and angioedema (13.2%). Hypotension was reported in 9 (2.2%) and syncope 5 (1.2%). Systemic steroid was prescribed in 143 patients (35.4%). After premedication, 139 patients (77.7%) had no hypersensitivity reactions to re-exposed RCM. Incidence of symptom after premedication such as uriticaria (12.4%), itching (5.6%), rash (5.1%), angioedema (2.2%) were significantly decreased compared with previous incidence (P 0.05) Conclusion The use of corticosteroid or antihistamine before administration of RCM may diminish the overall prevalence of reactions. Randomized controlled studies of the effects of pretreatment in patients with hypersensitivity reaction to RCM were needed.