Open AccessSuccessful desensitization in a patient with Von Willebrand´s disease and anaphylaxis to factor VIII/VW
Author(s) -
Olival Maristela,
Felix Mara,
Soares Monica,
Renni Marilia,
Montalvao Silmara,
Ensina Luis,
Castells Mariana
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p61
Subject(s) - medicine , itching , desmopressin , desensitization (medicine) , allergy , von willebrand disease , anaphylaxis , anesthesia , surgery , von willebrand factor , dermatology , immunology , platelet , receptor
Background Von Willebrand s disease (VWD) is the most common congenital disorder of hemostasis, characterized by deficient or defective von Willebrand factor. Patients are treated by intravenous replacement of factor VIII/VW (FVIII/ VW) when needed, for prophylaxis before surgical procedures. Anaphylactic reactions to FVIII/VW are rare and desmopressin (DDAVP) can be used as an alternative.